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KMID : 0613320030090020169
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Journal of the Korean Bone and Joint Tumor Soceity
2003 Volume.9 No. 2 p.169 ~ p.177
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Expression of p21, p27 in Osteosarcoma and Its Prognostic Significance
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Oh Joo-Han
Lee Sang-Hoon
Cho Hwan-Seong
Yoo Kwang-Hyun
Kim Jin-Sam
Gong Hyun-Sik
Suh Sung-Wook
Kim Ji-Eun
Kim Han-Soo
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Abstract
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Purpose: The purpose of the current study is to evaluate the correlation between the expressions of p21 and p27 in osteosarcoma, and prognostic impact such as local recurrence, distant metastasis and survival rate.
Materials and methods: Between 1988 and 2001, forty patients who underwent surgery, followed more than 12 months, and whose pathologic blocks were available, were evaluated retrospectively. Their formalin-fixed and paraffin-embedded tumor specimens were investigated. The correlation between expressions of p21, p27, local recurrence, distant metastasis and survival rate was statistically evaluated.
Results: p21 protein was expressed in 38 (95%) patients. p27 protein was expressed in 14 (35%) patients. Patients with high expression of p21 had more frequent metastasis and poorer results (p=0.024). In contrast with these findings, patients with positive staining of the p27 had the significant lower distant metastasis (p=0.028).
Conclusion: The prognosis of the osteosarcoma according to the expression level of p21 and p27 had inverse relationship which had unknown mechanism. Further work will be needed to define the relationship between p21 and p27.
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KEYWORD
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Osteosarcoma, p21, p27, Prognosis
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